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Create Date | July 13, 2022 |
Update Date | July 13, 2022 |
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Summary of Pharmacokinetics
Pharmacokinetics is currently defined because the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is that the application of pharmacokinetic principles to the safe and effective therapeutic management of medication in an individual patient.
Primary goals of clinical pharmacokinetics include enhancing efficacy and decreasing toxicity of a patient’s drug therapy. the event of strong correlations between drug concentrations and their pharmacologic responses has enabled clinicians to use pharmacokinetic principles to actual patient situations.
The property of kinetic homogeneity is very important for the assumptions made in clinical pharmacokinetics. it's the muse on which all therapeutic and toxic plasma drug concentrations are established. That is, when studying concentrations of a drug in plasma, we assume that these plasma concentrations directly relate to concentrations in tissues where the disease process is to be modified by the drug (e.g., the central nervous system in Parkinson’s disease or bone in osteomyelitis). This assumption, however, may not be true for all drugs.
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