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Summary of Multiple - Dosage Regimens

Generally, drugs are given in multiple doses to treat chronic disease like arthritis, hypertension, etc. After single-dose drug administration, the plasma drug level rises above so falls below the minimum effective concentration (MEC), leading to a decline in therapeutic effect. To treat chronic disease, multiple-dosage or IV infusion regimens are accustomed maintain the plasma drug levels within the narrow limits of the therapeutic window (eg, plasma drug concentrations above the MEC but below the minimum toxic concentration or MTC) to realize optimal clinical effectiveness. These drugs may include antibacterials, cardiotonics, anticonvulsants, hypoglycemics, antihypertensives, hormones, and others. Ideally, a dosage regimen is established for every drug to produce the right plasma level without excessive fluctuation and drug accumulation outside the therapeutic window.