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Summary of Application of Design of dosage regimens

The purpose of a dosage regimen design is, for the drug-native patient, to initiate therapy for multiple dosing. Since there's no drug within the body, mean literature pharmacokinetic parameters are used. The mean pharmacokinetic parameters should result at steady state in blood levels near the required ones but may lead to greatly increased blood levels in cases of renal and/or hepatic failure, myocardial or coronary infarction, other pathological conditions, or genetically different drug disposition.