Hard gelatin capsules: Introduction, Production of hard gelatin capsule shells. size
of capsules, Filling, finishing and special techniques of formulation of hard gelatin
capsules, manufacturing defects. In process and final product quality control tests
for capsules.
Soft gelatin capsules: Nature of shell and capsule content, size of
capsules,importance of base adsorption and minim/gram factors, production, in
process and final product quality control tests. Packing, storage and stability testing
of soft gelatin capsules and their applications.
2. Pellets : Introduction, formulation requirements, pelletization process, equipments for
manufacture of pellets
1. Capsules
Capsules are a convenient way to give powdered herbs because they conceal unpleasant tastes or textures. A drawback is that even large capsules can only hold 300 to 600 mg of powdered herb, which suggests that sometimes many capsules must be taken to realize adequate doses. Capsules containing herbal formulations are subject to the identical limitation of flexibility as tablet formulations. Single herbs in capsules do confer prescription flexibility, since one merely prescribes each of the specified herbs in capsule form. The disadvantage is that the patient may have to require an outsized number of capsules so as to realize adequate doses for several herbs.
2. Pellets
In pharmaceutical industries, pellets are multiparticulate dosage form which was formed
by the agglomeration of fine powdered excipient and medicines together that results in the
formation of small free flowing spherical or semi spherical particles. this system is
called as pelletization process. Pellets are typically varied between 500-1500 µm in size
for pharmaceutical applications. it's of great interest over other similar techniques due
to its uniformity of dose, less susceptibility of dose dumping, less friability etc. With the
advent of controlled release technology, drug loaded pellets are widely investigated
for its control release property in alimentary canal. This review will provide an insight
into previous studies on pelletization techniques, investigation of varied pelletization
techniques namely: layering, extrusion spheronization, cryopelletization, hot melt
extrusion. It also gives a quick idea about the evaluation of pellets; parameters affecting
pelletization, the various available marketed pellet formulation.
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