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Syllabus of Unit 3 :-

1. Capsules :-
  • Hard gelatin capsules: Introduction, Production of hard gelatin capsule shells. size of capsules, Filling, finishing and special techniques of formulation of hard gelatin capsules, manufacturing defects. In process and final product quality control tests for capsules.
  • Soft gelatin capsules: Nature of shell and capsule content, size of capsules,importance of base adsorption and minim/gram factors, production, in process and final product quality control tests. Packing, storage and stability testing of soft gelatin capsules and their applications.

2. Pellets : Introduction, formulation requirements, pelletization process, equipments for manufacture of pellets

1. Capsules

Capsules are a convenient way to give powdered herbs because they conceal unpleasant tastes or textures. A drawback is that even large capsules can only hold 300 to 600 mg of powdered herb, which suggests that sometimes many capsules must be taken to realize adequate doses. Capsules containing herbal formulations are subject to the identical limitation of flexibility as tablet formulations. Single herbs in capsules do confer prescription flexibility, since one merely prescribes each of the specified herbs in capsule form. The disadvantage is that the patient may have to require an outsized number of capsules so as to realize adequate doses for several herbs.

2. Pellets

In pharmaceutical industries, pellets are multiparticulate dosage form which was formed by the agglomeration of fine powdered excipient and medicines together that results in the formation of small free flowing spherical or semi spherical particles. this system is called as pelletization process. Pellets are typically varied between 500-1500 ┬Ám in size for pharmaceutical applications. it's of great interest over other similar techniques due to its uniformity of dose, less susceptibility of dose dumping, less friability etc. With the advent of controlled release technology, drug loaded pellets are widely investigated for its control release property in alimentary canal. This review will provide an insight into previous studies on pelletization techniques, investigation of varied pelletization techniques namely: layering, extrusion spheronization, cryopelletization, hot melt extrusion. It also gives a quick idea about the evaluation of pellets; parameters affecting pelletization, the various available marketed pellet formulation.