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Summary of Antimalarial

Antimalarial drugs are used for the treatment and prevention of malaria infection. Most antimalarial drugs target the erythrocytic stage of malaria infection, which is that the phase of infection that causes symptomatic illness. The extent of pre-erythrocytic (hepatic stage) activity for many antimalarial drugs isn't well characterized.

Treatment of the acute blood stage infection is critical for malaria caused by all malaria species. additionally, for infection because of Plasmodium ovale or plasmodium, terminal prophylaxis is required with a drug active against hypnozoites (which can remain dormant within the liver for months and, occasionally, years after the initial infection).

The mechanisms of action, resistance, and toxicities of antimalarial drugs are going to be reviewed here. Use of those agents for prevention and treatment of malaria is discussed thoroughly separately. (See "Prevention of malaria infection in travelers" and "Treatment of severe malaria" and "Treatment of uncomplicated falciparum malaria in nonpregnant adults and children".)