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Syllabus of Unit 4 :-

Drugs acting on Endocrine system
  1. Nomenclature, Stereochemistry and metabolism of steroids
  2. Sex Hormones : Testosterone, Nandralone, Progestrones, Oestriol, Oestradiol, Oestrione, Diethyl stilbestrol.
  3. Drugs For Erectile Dysfunction : Sildenafil, Tadalafil.
  4. Oral Contraceptives : Mifepristone, Norgestril, Levonorgestrol
  5. Corticosteroids : Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone
  6. Thyroid and Antithyroid Drugs : L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole

1. Sex Hormones

Sex hormones, also called sex steroids, gonad corticoids and gonadal steroids, are hormones that interact with vertebrate steroid hormone receptors The sex hormones include the androgens, estrogens, and progestogens. Their effects are mediated by slow genomic mechanisms through nuclear receptors yet as by fast nongenomic mechanisms through membrane-associated receptors and signaling cascades. The polypeptide hormones ICSH, gonadotropin and gonadotropin-releasing hormone are usually not considered sex hormones, although they play major sex-related roles.

2. Corticosteroids

Commonly named as steroids, corticosteroids are a kind of medicament. they're typically accustomed treat rheumatologic diseases, like atrophic arthritis, lupus or vasculitis (inflammation of the blood vessels). Specific corticosteroids include the medications cortisone and prednisone.

Corticosteroids are man-made drugs that closely resemble cortisol, a hormone that your adrenal glands produce naturally. Corticosteroids are often named by the shortened term "steroids." Corticosteroids are different from the male hormone-related steroid compounds that some athletes abuse.

3. Oral Contraceptives

Oral contraceptives (birth control pills) are hormone-containing medications that are taken orally to stop pregnancy. They prevent pregnancy by inhibiting ovulation and also by preventing sperm from penetrating through the cervix.

By far the foremost commonly prescribed form of contraceptive within the u. s. contains synthetic versions of the natural female hormones estrogen and progesterone. this kind of contraception pill is usually called a combined preventive. Another variety of contraceptive, sometimes called the mini pill, contains only progestin, which may be a man-made version of progesterone.