Version  1.0
 File Size  774 kb
 File Count  1
 Create Date  July 13, 2022
 Update Date  July 13, 2022
 Telegram  Join Now



You have to wait 15 seconds.



Summary of Sulphonamide and Sulphones

1. Sulphonamides
The sulphonamides are derivatives of sulphanilamide, which is that the amide of sulfanilic acid (4-aminobenzene sulphonic acid). The individual drugs are characterised by a selected substituent, R, at the amido nitrogen of sulphanilamide which is commonly noted as Nl , whereas their amino nitrogen cited as N4 must be free (unsubstituted). In many of the sulphonamides in current use as antibacterial drugs and all told those used as antimalarials, R may be a six-membered aromatic ring (a pyrimidine or a pyrazine) with one or two methoxy groups.

2. Sulphones
The sulphones utilized in chemotherapy - mainly in leprosy and, secondarily, in malaria - are bis (4-aminophenyl) sulphone (dapsone) and some derivatives thereof, mostly with two equal substitutents Rl = R2 at the 2 amino groups. The most important drugs are dapsone itself, and its bis-formyl and bis-acetyl derivatives which essentially act as chemical slow releasers of the parent compound