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Summary of Autacoids :-

Autacoids or "autocoids" are biological factors (molecules) which act like local hormones, have a quick duration, and act near their site of synthesis. The word autacoid comes from the Greek words "autos" (self) and "acos" (relief; i.e., drug). the results of autacoids are primarily local, though large quantities are often produced and moved into circulation. Autacoids may thus have systemic effects by being transported via the circulation. These regulating molecules are metabolized locally. In sum, these compounds typically are produced locally, act locally and are metabolized locally. Autacoids can have a spread of various biological actions, including modulating the activities of smooth muscles, glands, nerves, platelets and other tissues.

Some autacoids are chiefly characterized by the effect they need on specific tissues, like smooth muscle. With relevancy vascular smooth muscle, there exist both vasoconstrictor and vasodilator autacoids. Vasodilator autacoids are released during times of exercise. Their main effect is seen within the skin, where they facilitate heat loss.

These are local hormones; they therefore have a paracrine effect. Some notable autacoids are: eicosanoids, angiotensin, neurotensin, NO (nitric oxide), kinins, histamine, serotonin, endothelins and palmitoylethanolamide.

In 2015, a replacement definition of autacoids was proposed, which helps to more specifically describe Autacoid Medicine: '“Autacoids are a locally produced modulating factors, influencing locally the function of cells and/or tissues, which are produced on demand and which subsequently are metabolized within the same cells and/or tissues".