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Syllabus of Unit 1 :-

Pharmacology of drugs acting on cardio vascular system
  1. Introduction to hemodynamic and electrophysiology of heart.
  2. Drugs used in congestive heart failure
  3. Anti-hypertensive drugs
  4. Anti-anginal drugs
  5. Anti-arrhythmic drugs
  6. Anti-hyperlipidemic drugs.

1. Congestive Heart Failure

Heart failure doesn’t mean the center has stopped working. Rather, it means the guts works less efficiently than normal. because of various possible causes, blood moves through the guts and body at a slower rate, and pressure within the heart increases. As a result, the guts can’t pump enough oxygen and nutrients to fulfill the body's needs.

The chambers of the center may respond by stretching to carry more blood to pump through the body or by becoming stiff and thickened. This helps to stay the blood moving, but the center muscle walls may eventually weaken and become unable to pump as efficiently. The kidneys may respond by causing the body to retain fluid (water) and salt. If fluid builds up within the arms, legs, ankles, feet, lungs, or other organs, the body becomes congested. Congestive heart disease is that the term wont to describe the condition.

2. Hypertension

Hypertension (HTN) is taken into account one among the leading causes of increased disorder. Lowering vital sign does reduce cardiovascular risks; maintaining systolic pressure of but 130 millimeter of mercury demonstrably prevents complications in patients with heart disease, diabetes, arteria coronaries disease, stroke, and other cardiovascular diseases. This activity discusses the rules for choosing the suitable antihypertensive medications. It presents the various classes for first, second, and third-line treatments for hypertension and highlights the indications and side effects. It highlights the studies done to match different classes of antihypertensive medications and indications for every class.

3. Anti-anginal drugs

An antianginal may be a drug employed in the treatment of cardiopathy, a signal of ischaemic heart condition. So, medicinal agents used for relieving or preventing pathological conditions related to insufficiency and therefore the related ischemic heart diseases are noted as antianginal drugs. the most drugs used for myocardial ischema therapy and for relieving pain in heart condition are nitrates and nitrites, like nitroglycerin, isosorbide dinitrate, and pentaerythritol tetranitrate, which help in lowering systemic venous and blood pressure. Also substances that suppress adrenergic systems of the guts like β-adrenoblockers and Ca2+ channel blockers, additionally as some older drugs like papaverine and dipyridamole, also are used for this purpose.