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Summary of Animal toxicology

Toxicology is that the study of the adverse effects of chemical, physical, or biological agents on people, animals, and therefore the environment.
Toxicologists are scientists trained to research, interpret and communicate the character of these effects.

Good Laboratory Practices

  • Regulations to confirm the integrity of information from nonclinical studies.
  • Within the USA, the GLPs are administered by the FDA, and are laid get into 21CFR Part 58
  • Other regulatory agencies (OECD, EPA) have their own sets of GLP regulations that are kind of like but not the image of those of the FDA.
  • Definitive preclinical studies must be GLP compliant

In Vitro Toxicology

  1. The crossover point between drug discovery and drug development.
  2. Provide information on mechanism(s) of action of a drug
  3. Provides an early indication of the potential for a few forms of toxic effects, allowing a call to terminate a development program before spending an excessive amount of money.

In vitro methods are widely used for :-
  1. Screening and ranking chemicals
  2. Studying cell, tissue, or target specific effects
  3. Improve subsequent study design